Abstract
A ‘remedy for all’ natural product widely known in the Korean Peninsula is called Panax Ginseng Meyer. Globalization represents a persistent risk to the ozone layer, leading to bountiful amounts of Ultra-Violet B beams (UVB). The variety in human skin hues is ascribed to the characteristic color called Melanin. However, Melanin overproduction due to UVB beams promotes skin staining and tumorigenesis, a process called photo aging, which damages skin quality. To assess the effects of Korean Red Ginseng Oil (KGO) on photo aging, the murine melanoma cell lines B16/F10 were used in vitro and HRM-2 hairless mice exposed to UVB were studied in vivo. Our results revealed that KGO reduced tyrosinase activity and melanin production in B16/F10 cells along with the suppression of upstream factors involved in the melanin production pathway, both transcriptionally and transitionally. In the in vivo studies, KGO suppressed the expression of Matrix Metalloproteinase (MMP) and Interleukins along with a reduction of depth in wrinkle formation and reduced collagen degradation. Moreover, the feed intake and feed efficiency ratio that decreased as a result of UVB exposure was also improved by KGO treatment. In light of our results, we conclude that KGO can have considerable benefits due to its various properties of natural skin enhancement.
Highlights
Melanin is an intensifying agent that gives our skin its shading
We assessed the dietary intake and dietary productivity of HRM-2 mice exposed to Ultra-Violet B beams (UVB) for 5 weeks and given sunblock with Korean Red Ginseng Oil (KGO) salve applied on the skin
Melanocytes associated with the transportation of melanin tothat neighboring keratinocytes structuring theare layer of skin pigmentation
Summary
Melanin is an intensifying agent that gives our skin its shading. The assortment of skin hues between different humans is credited to melanin creating cells in the body. The body weights of the control mice in the UVB group decreased, yet the mice in the positive control with sunblock application and KGO salves demonstrated an increase in body weight when contrasted with the control UVB mice. Food intake was discovered to be expanded for the positive control and KGO salve groups, as shown in Introduction to UVB may induce a loss of appetite. We assessed the dietary intake and dietary productivity of HRM-2 mice exposed to UVB for 5 weeks and given sunblock with KGO salve applied on the skin.
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