Abstract
Whitening cosmetics with anti-melanogenesis activity are very popular worldwide. Many companies have tried to identify novel ingredients that show anti-melanogenesis effects for new product development. Among many plant-derived compounds, polyphenols are thought to be one of the most promising anti-melanogenesis ingredients. In order to prepare effective whitening polyphenols, 3,3,4,5,7-pentahydrosyflavone (quercetin) has been widely researched and applied to commercial products because it is present in high levels in many edible plants. Quercetin is thus a representative polyphenol and has recently gained attention in the cosmetics field. There are many controversies, however, regarding the effect of quercetin, based on in vitro studies, cell line experiments, and human trials. In this review, toxicity and efficacy data for quercetin and its derivatives in various experimental conditions (i.e., various cell lines, concentration ranges, and other parameters) were examined. Based on this analysis, quercetin itself is shown to be ineffective for hypopigmentation of human skin. However, a few types of quercetin derivatives (such as glycosides) show some activity in a concentration-dependent manner. This review provides clarity in the debate regarding the effects of quercetin.
Highlights
Melanin plays a significant role in the prevention of skin damage [1]
This review describes the fundamental synthesis of melanin, melanin signaling pathways, and the factors involved in melanogenesis and pigmentation disorders
The anti-melanogenesis effect of quercetin is not clear and it remains remains to be determined whether it induces an increase or decrease in melanin content. to
Summary
Melanin plays a significant role in the prevention of skin damage [1]. the accumulation of an abnormal amount of melanin in various parts of the skin results in the development of pigmented patches that might be viewed as an aesthetic problem [2]. Skin-whitening ingredients have become the most important components of cosmetic and hygiene products. Skin-whitening ingredients that show hypo-pigmentation efficacy (i.e., anti-melanogenesis activity) are important. Research institutes, and companies have attempted to identify effective and safe anti-melanogenesis and/or safe skin-whitening ingredients [3]. This review describes the fundamental synthesis of melanin, melanin signaling pathways, and the factors involved in melanogenesis and pigmentation disorders. It examines the effects of the well-known whitening compound quercetin on the inhibition of melanogenesis. Toxicity and efficacy data regarding quercetin and its derivatives for various experimental conditions (i.e., various cell lines, concentration ranges, and other parameters) are examined in this review
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.