Anti-malarial and Multi-bioactive Co (II), Cu (II) and Ni (II) Salen Complexes: Synthesis, Characterization and Computational Studies.

Abstract

Herein, we report anti-malarial, anti-bacterial and anti-inflammatory activities of theN2O2 donor tetradentate salen ligand and its CoL, NiL, and CuL metal complexes. All the compoundswere synthesized and characterized by various spectroscopic analytical methods.Thein-vitro antimalarial investigations revealed that the complex CuL exhibited equipotency with quinine drug having IC50 value 0.25 μg/mL.The compound L shows significant inhibition of bacterial spp.viz.E. Coli, P. Aeruginosa, and S. Aureus (MIC=12.5-50μg/mL), while the compound CoL (MIC=12.5μg/mL) exhibited potency against gram-positive bacteria. In the in-vitro anti-inflammatory study, the compound CuL has moderate activity than other tested compounds. The compound CuL showedthe highest anti-malarial docking score with enzyme pLDH at -8.12 Kcal/mol. The DFT study also gives authentication of higher antimalarial activity of CuL due to high dipole moment. None of the potent compound was found cytotoxic towards verocell lines.