Abstract
Yana Qu1, Chengting Zi1,2, Peiyuan Sun1, Jun Sheng1,3* Xuanjun Wang1-3* and Jing Wang1,2* Author Affiliations 1Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming, Yunnan 650201, China 2College of Science, Yunnan Agricultural University, Kunming, Yunnan 650201, China 3State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Kunming, Yunnan 650201, China Received: September 09, 2021 | Published: September 23, 2021 Corresponding author: Jun Sheng, Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Kunming, Yunnan 650201, China Xuanjun Wang, Key Laboratory of Pu-er Tea Science, Ministry of Education, College of Science, Yunnan Agricultural University, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Kunming, Yunnan 650201, China Jing Wang, Key Laboratory of Pu-er Tea Science, Ministry of Education, College of Science, Yunnan Agricultural University, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Kunming, Yunnan 650201, China DOI: 10.26717/BJSTR.2021.38.006229
Highlights
Lung cancer is the leading cause of cancer-related mortality around the world, with an estimated 1.8 million death [1], posing a serious threat to human health
The results observed that Rg3 decreased the levels of p-STAT3, p-Akt, and p-Erk. These results revealed that Rg3 induced apoptosis in A549 cells by down-regulating epidermal growth factor receptor (EGFR) signaling pathway
This review provides assurances that molecular mechanisms of anti-lung cancer activity employed by ginsenosides mainly involve induction of apoptosis, inhibition of proliferation, angiogenesis, invasion and migration, and regulation of cell cycle (Figure 8)
Summary
Lung cancer is the leading cause of cancer-related mortality around the world, with an estimated 1.8 million death [1], posing a serious threat to human health. Plant-derived natural active ingredients become a research hotspot, and show the advantages of rich variety and low toxicity. Ginsenosides, derived from the plants of Araliaceous family, including ginseng H.) and American ginseng (Panax quiquefolium L.), are responsible for most of the pharmacological activities of ginseng. Some ginsenosides have shown great anti-cancer activity [2]. Some studies have reported that ginsenosides performed their anti-lung cancer effects by affecting some signaling pathway and down-regulating various oncogenic proteins, no specific reviews conduct . The purpose of this review is to provide a summary of the anti-cancer effects and the potential mechanisms about ginsenosides of some most recent findings. We will hope that this review may provide valuable insights into application of ginsenosides for treatment of lung cancer
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