Abstract
Liver cancer is a malignant tumor with poor prognosis but high incidence and mortality rates. To date, its emergence and development mechanism remains ambiguous. This malignancy is mainly treated through multidisciplinary comprehensive treatment. After the extraction and structural identification of diaportheins fromPopulus lasiocarpa, its anti-liver cancer activity was examined in this study. First, the suppression effect of diaportheins against the viability of liver cancer cells was detected using the Cell Counting Kit-8. The influence of the extract on the invasion and migration ability of the cancer cells was also determined by Transwell detection. Posture scoring software and molecular docking were employed to explore the possible binding models between the target proteins and the compound. Finally, the neighbor-joining phylogenetic tree of thePopulusspecies was also analyzed.
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