Abstract
Six major tyrocidines, purified from the antibiotic tyrothricin complex produced by Bacillus aneurinolyticus, showed significant lytic and growth inhibitory activity towards the Gram+ bacteria, Micrococcus luteus and Listeria monocytogenes, but not against the Gram− bacterium, Escherichia coli. The isolated natural tyrocidines were in particular more active against the leucocin A (antimicrobial peptide) resistant strain, L. monocytogenes B73 -MR1 , than the sensitive L. monocytogenes B73 strain . Remarkably similar structure–activity trends toward the three Gram+ bacteria were found between growth inhibition and different physicochemical parameters (solution amphipathicity, theoretical lipophilicity, side-chain surface area and mass-over-charge ratio).
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