Abstract
ABSTRACT:The aim of the present study was to evaluate the therapeutic properties of selected fern, Chelianthusalbomarginataand to identify its functional compounds. The methanolic fern-extract (MFE) of these ferns was assessed for anti-bacterial activities by measuring inhibition zones against a panel of pathogenic bacterial strains using agar diffusion method. MFE at a concentration of 25 μg/ml showed marked anti-bacterial activity against all bacterial strains (6-23mm zone of inhibition) and was maximum against Enterobacter sp (23 mm). In addition, the MFE of C. albomarginatahad the best MIC values of 2.25µg/ml against S. aureus and Enterobacter sp., respectively. The MFE also possessed good anti-lipolytic activity (66.5%) against a porcine pancreatic lipase (PPL) and cholesterol oxidase inhibition (79%). This result showed that MFE of C. albomarginataunder optimal concentrationis not only a potent source of natural anti-oxidants and anti-bacterial activity but also possesses efficient cholesterol degradation and anti-lipolytic activities, that is to be beneficial in the body weight management.
Highlights
Chelianthesalbomarginata is a member of Adiantaceae family, which can grow up to 60 cm in length
methanolic fern-extract (MFE) has potential to inhibit the growth of many common bacterial pathogens
It may be suggested that the plants/tea extracts may possess effective antimicrobial activities that may be explored in the management of common bacterial infectious diseases
Summary
Chelianthesalbomarginata is a member of Adiantaceae family, which can grow up to 60 cm in length. Ferns offer us bioactive molecules that may serve as safer therapeutics to combat existing new world diseases. The screening of medicinally important fern extracts for antibacterial activity may be beneficial for humans and animal diseases [1]. People use traditional herbs to treat a variety of diseases including bacterial infections, but nowadays bacterial strains resistant most of the antibiotics and drugs [2] which cause approximately one-half of all death in world. Plants are the only common sources of potentially valuable new drugs. This provokes us to assess ferns as a source of potential chemotherapeutic agents for antimicrobial and anti-lipolytic activity based on their ethnomedicinal properties. The common diseases that could be treated by ferns include, ulcers (used fern stem juice), dysentery, and as protective medicine after childbirth [4]
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