Anti-Lipase and Antioxidant Activities of the Selected Plant Materials

Abstract

Pancreatic lipase plays an important role in the efficient digestion of triglycerides. Its action on lipids produces fatty acids, accumulating in excess into various tissues leading to dyslipidaemia and associated co-morbidities. Thus, inhibition of pancreatic lipase is one of the preferable ways to prevent such conditions. The present study is aimed to evaluate the anti-lipase and antioxidant activities of the leaves of Magnifera indica L. (mango), Psidium guajava L. (guava) and Moringa olifera L. (moringa), and fresh rhizomes of Zingiber officinale R. (ginger), Curcuma longa L. (turmeric), and Curcuma amada R. (mango ginger). The selected samples were dehydrated, powdered, and extracted using absolute ethanol. The extracts were analysed for total phenols, flavonoids, DPPH radical scavenging activity and anti-lipase activity. Among the selected leaves, mango leaves had the highest total phenolic content (6300 mg GAE /100 g), total flavonoid content (6930 mg RE /100 g) and highest DPPH radical scavenging activity (14497.3 mgTE /100 g). The highest lipase inhibition (89.07%) was observed in guava leaves. In rhizomes, turmeric contained the highest total phenolic content (6570 mg GAE /100 g) and flavonoid content (14760 mg RE /100 g). Mango ginger possessed the highest DPPH radical scavenging activity of 9038.7 mg TE /100 g and lipase inhibition of 44.83%. The study concludes that guava leaves and mango ginger possess the highest anti-lipase activity among the selected leaves and rhizomes.