Abstract
AbstractA BALB/c mouse was immunized with fibrous proteins (FP) extracted from basal cell epithelioma (BCE) and anti‐keratin monoclonal antibodies were produced by a hybridoma technique with a mouse myeloma cell line. One monoclonal antibody was designated as BKN‐1.Immunohistochemically, in 17 cases of BCE, the cytoplasm of all the tumor cells was always stained by BKN‐1. In the normal human skin tissue, BKN‐1 specifically reacted with the basal cells in the epidermis and in the infundibular epithelium of the hair follicle, the entire follicular cells below the isthmus portion in the anagen hair follicle, the peripheral cells of sebaceous glands, and sweat gland cells. The reaction of BKN‐1 was immunoelectron microscopically located on the tonofilaments in the cytoplasm. By immunoblot analysis, BKN‐1 stained either a band of 56–56.5K in FP from BCE or several bands in normal epidermal FP.These results suggest that the keratin expression of BCE may resemble that of the follicular epithelium below the isthmus portion.
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