Anti-Ischaemic Efficacy of Amlodipine vs Nifedipine in the Treatment of Patients with Stable Exertional Angina

Abstract

The anti-ischaemic effects of amlodipine were compared with those of sustained release nifedipine in 53 patients with exertional angina. After a 1-week drug washout phase, patients were randomised to receive amlodipine (5mg once daily) or sustained release nifedipine (20mg twice daily). After 2 weeks of treatment, initial doses were doubled if there was inadequate control of symptoms in the absence of adverse events.