Abstract
SPECIFIC AIMSEpigallocatechin-3-gallate (EGCG), the main polyphenol component of green tea, exerts inhibitory action on urokinase, metalloproteinase, and inducible nitric oxide synthase (NOS II), accounting for its antitumor and anti-inflammatory action. The aim of the present study was to identify in human cell lines the molecular target of EGCG that modulates the expression of a number of genes involved in inflammatory and neoplastic processes.PRINCIPAL FINDINGS1. EGCG blocks interferon γ (IFN-γ)-elicited activation of signal transducers and activators of transcription 1 (STAT1) by interfering with tyrosine phosphorylation in human MDA MB 231 cell lineTreatment of the estrogen nonresponsive human mammary carcinoma cell line MDA MB 231 with lipopolysaccharide (LPS)/IFN-γ/tumor necrosis factor (TNF)-α/interleukin 1β (IL-1β) (MIX) promptly induced the activation of a nuclear factor, NF-κB, that was not affected by the pretreatment with 20 μM EGCG; 20 μM EGCG did not inhibit the constitutively activated nuc...
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