Abstract
• Four new patchoulol-type sesquiterpenoids were isolated from Pogostemon cablin (Blanco) Benth. • This is the second report of patchoulol glucopyranoside from P. cablin . • Compound 10 represented as the first example of nor-patchoulol glucopyranoside. • Compounds 8 and 12 showed potent anti-influenza activity against tamiflu resistant virus. Four new patchoulol-type sesquiterpenoids, including 6 α ,9 β -dihydroxypatchoulol 6- O - β - d -glucopyranoside ( 1 ), 6 α -hydroxypatchoulol 6- O - β - d -glucopyranoside ( 2 ), 3 α ,9 β -dihydroxypathoulol ( 3 ), and 4 β -hydroxynorpatchoulol 4- O - β - d -glucopyranoside ( 10 ), were isolated from the roots of Pogostemon cablin (Blanco) Benth, together with eleven known sesquiterpenoids. Their structures were elucidated on the basis of extensive NMR spectral and high resolution mass spectrometry analysis. This is the second report of patchoulol glucopyranoside from P. cablin and compound 10 represented as the first example of nor-patchoulol glucopyranoside. The anti-influenza virus activities of 1–10 against A/WSN/33/2009 and A/Puerto Rico/8/1934 strains (tamiflu resistant viruses) were evaluated. Compounds 2 β ,12-dihydroxypathoulol ( 5 ) and (5R)-5-hydroxypatchoulol ( 8 ) exhibited moderate anti-influenza activity against A/WSN/33/2009 strain with EC 50 value of 52.7 μ M and 49.6 μ M (positive control oseltamivir, EC 50 = 6.75 μ M). Compounds 8 and pogostol ( 12 ) showed potent anti-influenza activity against A/Puerto Rico/8/1934 strain with EC 50 values of 3.06 μ M and 0.07 μ M, respectively, versus the postive control (amantadine, EC 50 = 67.9 μ M).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.