Abstract
AbstractInflammation is a physiological process that involves a variety of inflammatory mediators such as PGE2, Nitric oxides, PLA2 etc., blocking these mediators could be helpful in designing and development of promising anti‐inflammatory compounds. Non‐steroidal anti‐inflammatory drugs (NSAIDs) have been used for the treatment of inflammatory‐related disorders via variety of pathways that include inhibition of COX‐1, COX‐2, LOX, NO etc. Chalcone derivatives, characterized by their unique chemical structure, have emerged as potential candidates for modulating inflammatory pathways. Literature suggested that modifications in chalcone derivatives by targeting different molecular targets could leads to the development of potential anti‐inflammatory agents. In this review, we have summarised representative chalcone derivatives against different anti‐inflammatory targets and discussed their structure‐activity relationship along with relevant data.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
