Anti-inflammatory effects of tellurium dioxide -niobium pentoxide nanocomposite coatings on titanium implants

Abstract

Replacement of joints is a significant subspecialty of bone replacement surgery that calls for mechanically robust and biologically compatible, or biocompatible, implants. In this study, incorporating tellurium dioxide with niobium pentoxide is an effective method to impart the coatings with antibacterial properties by a thermal decomposition method on titanium substrate. The developed coatings were treated for alkaline treatment and was subjected for in vitro study in 1.5 Kukubo’s simulated body fluid to enhance biogrowth and adhesion strength. The physico-chemical and surface characterization revealed the presence of nanocomposite coatings with the deposition apatite on the surface of titanium metal strip was confirmed by XRD, FTIR, EIS, CV, SEM and AFM analysis studies. The electrochemical experiments revealed that the developed coatings had high adhesion strength and great biomimetic growth characteristics. The antibacterial test was used to evaluate the antibacterial properties of tellurium dioxide-niobium pentoxide coatings respectively. Antibacterial assays determined that treatment with nanocomposite coating at concentrations of 0.62 to 5 µg/mL induced a decay in the growth of both Gram-negative and Gram-positive bacteria. The highest zone of inhibition was observed for Staphylococcus aureus and Escherichia coli respectively. These properties show that for the first time, tellurium dioxide-niobium pentoxide nanocomposite coating can be used as a powerful inflammatory agent. In summary, this study provided an alternative method to prepare the nanocomposite coating with low temperature, low-cost technique can promote the physico-chemical interaction to effectively fabricate bioactivity with antibacterial and anti-inflammatory ability for bioimplants.