ANTI-INFLAMMATORY EFFECTS OF SIMHASYADI KASHAYA AND GHANAVATI

Abstract

Simhasyadi kashaya mentioned in Chakradatta contains Guduchi, Vasa and Brihati, which are readily available in our surrounding area. It is indicated for Shopha, Swasa, Kasa, Jwara and Chardi. In contrast, Simhasyadi Ghanavati is taken on the hypothesis that Ghanavati is more effective than kwatha. Apart from these, vatis are more durable, and medicinal value can be maintained for a more extended period, easy to administer and easy to store. In the present study, Simhasyadi Kashaya and ghanavati were prepared by standardised methods and tested in albino rats for anti-inflammatory action. The rats of either sex weighing 150 to 250 gm are used in this experiment. The control rats receive 1 ml of distilled water; the standard group is given ibuprofen suspension, test group A given oral administration of Simhasyadi kwatha and test group B given Simhasyadi ghanavati orally. After 1 hour, the rats are injected with 0.05 ml of 1% carrageenan solution subcutaneously into the plantar side of the left hind paw. The paw is marked with ink at the level of the lateral malleolus and immersed in mercury up to this mark. The paw volume is measured plethysmographically immediately after injection and again after 30 min, 60 min, 120 min, 180 min and after 12 hours and eventually 24 hours after challenge. The statistical tests proved that the trial drugs, Simhasyadi kashaya and Ghanavati, had a significant anti-inflammatory effect compared to the control and standard groups. It maintained a constant lower than the control level because of its residual anti-inflammatory action.