Anti-inflammatory effects of hyperbaric oxygen on irradiated laryngeal tissues

Mitat Arıcıgil,Mehmet Akif Dündar,Abitter Yücel,Hamdi Arbağ,Abdullah Arslan,Meryem Aktan,Sıdıka Fındık,İbrahim Kılınç

doi:10.1016/j.bjorl.2017.02.001

Mitat Arıcıgil, Mehmet Akif Dündar + Show 6 more

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https://doi.org/10.1016/j.bjorl.2017.02.001

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Abstract

IntroductionTo manage the complications of irradiation of head and neck tissue is a challenging issue for the otolaryngologist. Definitive treatment of these complications is still controversial. Recently, hyperbaric oxygen therapy is promising option for these complications. ObjectiveIn this study, we used biochemical and histopathological methods to investigate the efficacy of hyperbaric oxygen against the inflammatory effects of radiotherapy in blood and laryngeal tissues when radiotherapy and hyperbaric oxygen are administered on the same day. MethodsThirty-two Wistar Albino rats were divided into four groups. The control group was given no treatment, the hyperbaric oxygen group was given only hyperbaric oxygen therapy, the radiotherapy group was given only radiotherapy, and the radiotherapy plus hyperbaric oxygen group was given both treatments on the same day. ResultsHistopathological and biochemical evaluations of specimens were performed. Serum tumor necrosis factor-α, interleukin-1β, and tissue inflammation levels were significantly higher in the radiotherapy group than in the radiotherapy plus hyperbaric oxygen group, whereas interleukin-10 was higher in the radiotherapy plus hyperbaric oxygen group. ConclusionWhen radiotherapy and hyperbaric oxygen are administered on the same day, inflammatory cytokines and tissue inflammation can be reduced in an early period of radiation injury.

Highlights

To manage the complications of irradiation of head and neck tissue is a challenging issue for the otolaryngologist
Pathological variations and their distributions in the specimens in all the groups are shown in Table 1 and Fig. 1
Changes related to the early effects of RT are either a result of increasing cell death from DNA injury or formation of Reactive Oxygen Species (ROS), whereas late changes related to RT are a result of vascular injury and fibrosis

Summary

Introduction

To manage the complications of irradiation of head and neck tissue is a challenging issue for the otolaryngologist. Objective: In this study, we used biochemical and histopathological methods to investigate the efficacy of hyperbaric oxygen against the inflammatory effects of radiotherapy in blood and laryngeal tissues when radiotherapy and hyperbaric oxygen are administered on the same day. Irradiation of the neck region can be performed in the presence of neck lymph node metastasis from the larynx, or cancers of any other region, or in the various stages of laryngeal cancer.[2] Apart from the therapeutic nature of radiotherapy, it has definite hazardous effects on the surrounding tissues and these effects can occur at either early or late stages. Mucositis, Soft Tissue Radionecrosis (STRN), Osteoradionecrosis (ORN), and Laryngeal Radionecrosis (LRN) are some of the examples of these side effects.[2,3]

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