Abstract
Anti-Inflammatory Effects of Evening Primrose and Extra Virgin Olive Oil on Arthritc Rats
Highlights
Rheumatoid arthritis (RA) is an autoimmune illness with a percentage of 1% of the population
Ankle edema diameter and blood cells count Arthritic rats showed significant enlargement in ankle sizes at 10 and 21 days, and most potent increases were recorded at 10 days post-CFA injection
White blood cells were raised in arthritic groups as compared with normal groups in study periods (Table 1 and Figure 2)
Summary
Rheumatoid arthritis (RA) is an autoimmune illness with a percentage of 1% of the population. It affects women more than men (Narendhirakannan et al, 2007). Freund’s complete adjuvant (FCA) mirrors the pathology of RA with hyperplasia of the synovial tissues, joints inflammation, and demolition of the cartilages and bones in the affected area (Saratha and Subramanian, 2012). Evening primrose oil (EPO) is extorted from Oenothera Biennis seeds. EPO was evaluated medically for its therapeutic influence to treat different diseases in controlled clinical trials like rheumatoid arthritis, various cancers, breast cysts, and schizophrenia (Bayles and Usatine, 2009). Nutritional omega-3 and omega-6 fatty acids can oppose the bad effects of unsaturated fatty acids and eicosanoid actions in tissues, which cause various inflammatory and immunologic pathogenesis
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