Abstract
Although results of recent studies suggest that fermented foods strongly affect the gut microbiota composition and that they relieve inflammatory bowel disease symptoms, some reports have described that fermented foods increase some inflammation markers based on differences in fermented food materials. This study evaluated the effects of fermented plant extract (FPE) on dextran sulfate sodium (DSS)-induced colitis in mice and the effects on fecal microbiota composition in humans. Mice fed 5% FPE with 3% DSS (FPE group) showed no body weight loss, atrophy of colonic length, or bloody stool, similar to mice fed a basal diet (negative group), whereas mice fed 3% DSS (positive group) exhibited those effects. Concentrations of inflammation markers IL-6 and TNF-α were not significantly different between FPE and negative groups; however, those concentrations became higher in the positive group. 16S ribosomal RNA gene sequencing was used to characterize fecal microbiota in healthy women before and after 3-month FPE supplementation. The FPE supplementation induced increases in Firmicutes phyla and in Clostridiales order, which play a central role in inflammation suppression. These results suggest that FPE enhances Clostridiales growth in the gut and that it has an anti-inflammatory effect.
Highlights
IntroductionInflammatory bowel disease, as typified by diseases such as ulcerative colitis and
Our study study demonstrated demonstrated that the daily diet supplemented with fermented plant extract (FPE) directly prevented inflammation and changed the microbial composition in the gut, especially the increase of Clostridiales order, which plays a central role in suppressing inflammation, suggesting that FPE could improve the quality of human life against inflammatory bowel disease
The daily diet was supplemented with FPE
Summary
Inflammatory bowel disease, as typified by diseases such as ulcerative colitis and. The Japanese Ministry of Health, Labor, and Welfare has specified these diseases as intractable diseases. The number of patients with these diseases has been increasing in Japan [1,2]. Dysbiosis and disruption of immunological homeostasis have been associated with inflammatory diseases [3,4,5,6,7,8,9,10,11,12,13] because the gut microbiota affects immunologic, nutritional, and metabolic processes of the human body [14], indicating that diet strongly affects inflammatory bowel disease
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
