Abstract
Background: Anthocephalus cadamba (Rebox) Miq. (Rubiaceae) is widely distributed throughout the greater part of India, especially at low levels in wet place. Traditionally the bark is used as tonic, febrifuge and to reduce the pain and inflammation. The anti-inflammatory effect of methanol extract obtained from Anthocephalus cadamba aerial parts, MEAC, were investigated in this study. Design and methods: The effects of MEAC on the acute and chronic phases of inflammation were studied in carrageenan, dextran and mediators (histamine and serotonin) induced paw edema and cotton pallet-induced granuloma, respectively. The anti-edema effect of MEAC was compared with 10 mg/kg of indomethacin orally. Results: The results suggested that MEAC possess potent anti-inflammatory activity. The acute inflammatory model showed that all the doses of MEAC effectively suppressed the edema produced by histamine, so it may be suggested that its anti-inflammatory activity is possibly backed by its antihistaminic activity. In chronic inflammatory model the effect may be due to the cellular migration to injured sites and accumulation of collagen and mucopolysaccharide. Conclusions: On the basis of these findings, it may be inferred that Anthocephalus cadamba is an anti-inflammatory agent and the results are in agreement with its traditional use.
Highlights
The stem bark of the plant Anthocephalus cadamba was collected from Mangalore of Karnataka, India during December 2007
The animals were treated in a n manner similar to that of the carrageenano induced paw edema models; dextran (0.1 mL, 1% W/V in normal saline) was used in the place e of carrageenan.[6] us Histamine- and serotonin-induced l inflammation ia The rats were divided into five groups of six animals each
The different N groups were treated with MEAC
Summary
Contributions: KSC carried out practical work and wrote the paper; BA has helped in collecting the plant material, carrying out the extraction and administering the drug to the animals; KSP carried out data analysis, statistical work and Abstract nly Anthocephalus cadamba (Rebox) Miq. The anti-inflammatory u effect of methanol extract obtained from l Anthocephalus cadamba aerial parts, MEAC, ia were investigated in this study. The effects of MEAC on the acute and chronic phases of rc inflammation were studied in carrageenan, dextran and mediators (histamine and seroe tonin) induced paw edema and cotton palletm induced granuloma, respectively. The antiedema effect of MEAC was compared with 10 m mg/kg of indomethacin orally. Results suggested that MEAC possess potent anti-inflammatoo ry activity. The acute inflammatory model -c showed that all the doses of MEAC effectively suppressed the edema produced by histamine, n so it may be suggested that its anti-inflammao tory activity is possibly backed by its antihistaN minic activity.
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