Abstract
Background: Atopic Dermatitis (AD) is a chronic inflammatory skin disease that causes functional disruption of the skin barrier. We previously found that ethanol Extracts of Mallotus Philippinensis Bark (EMPB) promoted migration of mesenchymal stem cells and improved wound healing probably through anti-inflammatory action. However, direct evidence of the anti-inflammatory effect of EMPB and the underlying mechanisms of this action remain unknown. In the present study, we evaluated whether EMPB has an effective action on anti-inflammation using an in vitro and in vivo model. We found that topical application of EMPB improved house dust miteinduced AD-like skin inflammation in NC/Nga mice. In addition, EMPB significantly inhibited various kinds of inflammatory mediators such as interleukin-1ß, inducible nitric oxide synthases, and nuclear factorkappa B in lipopolysaccharide-stimulated macrophage cells. Moreover, EMPB exhibited marked radical scavenging ability. Taken together, these results suggest that EMPB may be useful in the treatment of skin inflammatory diseases such as AD. Keywords: Mallotus Philippinensis Bark; Anti-Inflammation; Atopic Dermatitis; Macrophages
Highlights
The Muell-Arg (Euphorbiaceae) plant Mallotus philippinensis is widely distributed and is used in traditional medicine [1]
In the Extracts of Mallotus Philippinensis Bark (EMPB) treatment group, the dermatitis score was lower from day 21 (D21) to D30 than that in the vehicle group; especially, significance was observed at D27 (Figure 1b, 1c, 1d)
We investigated the effects of EMPB on house dust mite-induced Atopic Dermatitis (AD)-like skin lesions in NC/Nga mice, an animal model of human AD [14,15]
Summary
The Muell-Arg (Euphorbiaceae) plant Mallotus philippinensis is widely distributed and is used in traditional medicine [1]. Our group demonstrated that ethanol Extract of Mallotus Philippinensis Bark (EMPB) promoted migration of mesenchymal stem cells (MSCs), enhanced MSCs homing to the wound sites, and improved remodeling in the wound healing process in a mouse model [2]. Little is known about the direct effect of EMPB on inflammatory response in vitro and in vivo. We previously found that ethanol Extracts of Mallotus Philippinensis Bark (EMPB) promoted migration of mesenchymal stem cells and improved wound healing probably through anti-inflammatory action. We evaluated whether EMPB has an effective action on anti-inflammation using an in vitro and in vivo model. Taken together, these results suggest that EMPB may be useful in the treatment of skin inflammatory diseases such as AD
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