Abstract
The increase in the rate of inflammation in the post-menopause period also leads to a significant increase in the use of anti-inflammatory agents. This study aimed to investigate the effect of BA supplementation on pro-and anti-inflammatory cytokines in ovariectomy (OVX) induced rats. A total of 48 nonpregnant female Wistar albino rats (80-100 g) were used in the experiment. Forty-eight rats were divided into six equal groups (n=8): Control, OVX, OVX+5 mg/kg BA (OVX+BA5), OVX+10 mg/kg BA (OVX+BA10), 5 mg/kg BA (BA5), 10 mg/kg BA (BA10). Serum TNF-α cytokine levels of rats in the OVX group were higher than in control rats (P<0.05). TNF-α levels were significantly reduced in the OVX-induced rats with 5 mg/kg BA and 10 mg/kg BA supplementation (P<0.05). While serum IL-1α and IL-6 levels were not different between OVX and control rats, serum IL-3 levels were low (P<0.05) and not affected by 5 mg/kg and 10 mg/kg BA supplementation. Serum IL-11 levels increased significantly in the OVX rats with 5 mg/kg and 10 mg/kg BA supplementation (P<0.05). As far as we know, certain doses (5 and 10 mg/kg) of BA are the first study on the prevention of increased inflammation in rats induced by OVX. Results suggest that the supplementation of BA regulates the inflammatory changes associated with OVX and thus has beneficial for menopause management.
Highlights
In an aging society, the postmenopausal female by many other cell types such as lymphocytes, natural killer (NK) population is increasing
The primary postmenopausal women worldwide was 477 million in role of TNF-α is the regulation of immune cells [2]
Interleukin 1 alpha (IL-1a) is menopause is often related to hormone insufficiency, accountable for promoting the generation of a factor that subscribes to a raised incidence of inflammation up to fever and sepsis [3]
Summary
The postmenopausal female by many other cell types such as lymphocytes, NK population is increasing. The primary postmenopausal women worldwide was 477 million in role of TNF-α is the regulation of immune cells [2]. Menopause is a turn-out spot in interleukin 1 family and is mainly synthesized by the life of every woman, the last period of activated macrophages as well as neutrophils and menstruation-related with the disruption of the epithelial cells. It has physiological, haematopoietic, activities of the ovarian follicle, resulting in the metabolic activities, and plays a role significant role persistent stopping of menstruation.
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