Abstract
The influence of anti-inflammatory drugs on development of atherosclerosis in cholesterol-fed rabbits has been studied. All of the steroids tested reduced plaque formation by 55–95% over the 12 week experimental period. The most potent, 9α-fluorohydrocortisone, was effective in oral doses of only 30 μg daily. Dexamethasone, methylprednisolone, triamcinolone, prednisone and cortisone acetate were also effective at higher dose levels. These protective effects were partially duplicated by a number of non-steroids including flufenamic acid, phenylbutazone, oxyphenylbutazone and mefanamic acid. Aminopyrine and aspirin were inactive. By means of dose-response curves, it was possible to demonstrate dissociation of the hyperlipemic effects of the steroids from their protective effects. It was found that the relative potencies of these drugs in inhibiting atherosclerosis in the rabbit, parallels closely their effectiveness in the treatment of inflammatory disorders in humans.
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