Abstract
Collaborative research guided by the traditional Indigenous knowledge of Northern Kaanju people, Cape York Peninsula, Australia has recently led to the isolation of four new clerodane diterpenoids from the leaves of Dodonaea polyandra (Sapindaceae). These compounds have shown high levels of anti-inflammatory activity in a TPA mouse ear oedema model of inflammation. Dose-response studies revealed compound CS004 (below) was the most potent of these displaying a linear dose-response relationship.
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