Abstract
Abstract − The current work was designed to assess novel pharmacological activities of 4-hydroxybenzalde-hyde (HD), a major phenolic constituent of various natural products of plant origin, such as Gastrodia elata Blume. HD exhibited a significant inhibition in the chick chorioallantoic membrane (CAM) angiogenesis. HD alsodisplayed an inhibitory effect in acetic acid-induced permeability in mice. Anti-nociceptive activity of HD wasconvinced using the acetic acid-induced writhing test in mice. HD was able to suppress production of nitricoxide (NO) and induction of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in thelipopolysaccharide (LPS)-activated RAW264.7 macrophages. HD also diminished the reactive oxygen species(ROS) level elevated in the LPS-activated macrophages. In brief, HD exhibits anti-angiogenic, anti-inflamma-tory and anti-nociceptive activities possibly via down-regulating iNOS and/or COX-2, which may be partlyresponsible for pharmacological efficacies of various natural products.
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