Abstract
Obesity is now recognized as a global health problem and has reached epidemic proportions, affecting both developed and developing countries. This condition is associated with an increased incidence in central nervous system (CNS) disorders. The intake of foods or supplements with anti-inflammatory activity could potentially lead to a lower impact of obesity on the functionality of CNS. Therefore, in this work we tested the effect of a dietary supplement, DEKOSILHUE® (DSK), containing polyphenols enriched herbal extracts and successfully used for improving the control of body weight, in an in vitro inflammatory model. LPS-stimulated immortalized microglia BV2 cells have been used as a model of neuroinflammation. The stimulation with LPS increased the release and activation of several neuroinflammatory mediators, such as IKB⍺, HDAC-1, and IL-1ß. DSK reduced the levels and the activation of all these pro-inflammatory markers. In addition, DSK increased the expression of the anti-inflammatory cytokine IL-10, promoting an anti-inflammatory response. Finally, we showed that the anti-inflammatory effect of DSK can prevent the neurotoxicity related to microglia hyperactivation. In conclusion, DSK could potentially help in controlling neuroinflammation CNS, reducing microglia pro-inflammatory activation.
Highlights
Accepted: 28 January 2022Obesity is recognized as a global health problem and has reached epidemic proportions, affecting both developed and developing countries
Genetic obesity can be found in some patients, it remains relatively rare [2] and predominantly results from environmental factors, such as diet type or physical activity level. This condition is associated with an increased incidence in central nervous system (CNS) disorders, such as dementia, stroke, depression, and Alzheimer’s disease [3]
The copresence of systemic inflammation and obesity was recognized some time ago, with early reported evidence suggesting that obese people have elevated circulating pro-inflammatory cytokines compared to control groups [19]
Summary
Accepted: 28 January 2022Obesity is recognized as a global health problem and has reached epidemic proportions, affecting both developed and developing countries. Genetic obesity can be found in some patients, it remains relatively rare [2] and predominantly results from environmental factors, such as diet type or physical activity level This condition is associated with an increased incidence in central nervous system (CNS) disorders, such as dementia, stroke, depression, and Alzheimer’s disease [3]. Following a “Western diet” alters glucose transporter function at the hippocampal level with severe cognitive deficits and increased anxiety levels [4], while a diet high in sugar predisposes to the development of depression These diseases have different etiologies and pathophysiological manifestations, they all share a neuroinflammatory component [5] and obese patients represent a population that is more prone to develop central disorders [6]. Increased adipose tissue affects the normal function of many organs, Published: 8 February 2022
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