Abstract
Many trials have been conducted to treat atopic dermatitis (AD), but these therapies are generally unsuccessful because of their insufficiency or side effects. This study examined the efficacy of β-glucan derived from oats with fermented probiotics (called Synbio-glucan) on an AD-induced mouse model. For the experiment, Nc/Nga mice were exposed to a house dust mite extract (HDM) to induce AD. The mice were placed in one of four groups: positive control group, Synbio-glucan topical treatment group, Synbio-glucan dietary treatment group, and Synbio-glucan topical + dietary treatment group. The experiment revealed no significant difference in the serum IgE concentration among the groups. Serum cytokine antibody arrays showed that genes related to the immune response were enriched. A significant difference in the skin lesion scores was observed between the groups. Compared to the control group tissue, skin lesions were alleviated in the Synbio-glucan topical treatment group and Synbio-glucan dietary treatment group. Interestingly, almost normal structures were observed within the skin lesions in the Synbio-glucan topical + dietary treatment group. Overall, the β-glucan extracted from oats and fermented probiotic mixture is effective in treating atopic dermatitis.
Highlights
IntroductionAtopic dermatitis (AD) is a common chronic inflammatory skin disease and a global public health concern because of its increasing prevalence and socioeconomic burden [1]
Atopic dermatitis (AD) is a common chronic inflammatory skin disease and a global public health concern because of its increasing prevalence and socioeconomic burden [1].Approximately 20% of people around the world suffer from AD [2]
This study examined the efficacy of β-glucan derived from oats with probiotics in an AD-induced mouse model
Summary
Atopic dermatitis (AD) is a common chronic inflammatory skin disease and a global public health concern because of its increasing prevalence and socioeconomic burden [1]. Many trials have been conducted to overcome AD, including antihistamines, glucocorticoids, and anti-microbial agents More advanced therapies, such as immunotherapy, have been used to treat AD. Β-glucan is a biologically activated polysaccharide found in the cell walls of algae, cereals, mushrooms, yeast, and some bacteria [9] This polysaccharide has potent immunomodulatory effects on the innate and adaptive immunity. One study reported that the oral administration of β-glucan derived from yeast (Aureobasidium pullulans) has anti-AD effects in animal models [14]. Another study indicated anti-AD effects through the topical administration of β-glucan derived from mushroom, Pleurotus ostreatus, on human patients [15]. This study examined the efficacy of β-glucan derived from oats with probiotics in an AD-induced mouse model
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