Abstract
ABSTRACT Portulide glucoside A ( 1 ), 14-acetoxy-9- epi -britanlin A ( 2 ), and dichroditerpene A ( 3 ) along with eight known compounds were isolated from Dichrocephala integrifolia . Diterpenoids 3 and 5 showed antineutrophilic inflammatory activities against not only superoxide anion generation with IC 50 values of 1.74 and 4.40 μM, but also elastase release with IC 50 values of 1.32 and 3.67 μM, respectively. Additionally, sinapyl alcohols 8 and 9 showed moderate cytotoxicity toward DU145 human prostate cancer cell line with IC 50 values of 24.1 and 19.0 μM, respectively. Isolates 1–10 were found for the first time in this plant.
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