Abstract
Objectives: Baphia nitida is a tropical plant used in African folkloric medicine for the treatment of infections and inflammatory conditions. This study therefore seeks to investigate the biological activities including antioxidant and anti-inflammatory properties of leaf and root methanol extracts of B. nitida. Methods: Anti-inflammatory activity of extract was investigated by the carrageenan-induced paw edema model of inflammation, respectively. The antioxidant properties of the extracts as determined by the DPPH free radical scavenging assay. Results: The result showed that B. nitida extract caused a concentration dependent percentage increase of antioxidant activity. The leaves and root extract demonstrated potent anti-inflammatory activity at low concentrations of between 25-75 mg /kg body weight. The ascorbic acid standard had a better antioxidant activity of 63.59% at the concentration of 10 µg/ml and 81.63% at 400 µg/ml. Conclusion: The methanol root extract at lower doses exhibited anti-inflammatory properties. Methanol leaf extract than the root extract. Both the leaf and root extracts of B. nitida exhibited antioxidant activity. Peer Review History: Article received on- 23 October, Revised on- 18 November, Accepted on- 29 December, Available online 15 January 2017 Academic Editor: Dr. Asia Selman Abdullah, Al-Razi university, Department of Pharmacy, Yemen, asia_abdullah65@yahoo.com Received file: Reviewer's Comments: Average Peer review marks at initial stage: 4.0/10 Average Peer review marks at publication stage: 7.0/10 Reviewer(s) detail: Dr. Xinwei Li, Jilin University, China, lixinwei100@jlu.edu.cn Prof. Dr. Ali Gamal Ahmed Al-kaf, Sana'a university, Yemen, alialkaf21@gmail.com Similar Articles: ANTI-HYPERGLYCEMIC AND ANTI-OXIDANT ACTIVITIES OF METHANOL EXTRACT OF GONGRONEMA LATIFOLIUM
Highlights
Anti-inflammatory and anti-oxidant activities of methanol extract of Baphia nitida
The anti-inflammatory activity of metabolic extract of leaves and root of B. nitida was investigated in rats using carrageenan induced paw oedema
DPPH is a stable free radical, it accepts an electron or following subplantar injection of carrageenan results hydrogen radical to become a stable from the release of serotonin, histamine and prostaglandin-like substances[15]
Summary
Anti-inflammatory and anti-oxidant activities of methanol extract of Baphia nitida. An antioxidant inhibits the oxidation of other animals used in experiments were followed in all tests. Three groups A, B and C (comprising attracted broader interest because of their role in of five animals each) of rats were treated orally with inhibiting free radical reactions and their help in Anti oxidant study DPPH antioxidant assay of the present study was to evaluate the anti-
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