Abstract
The methanol leaf extract of Mallotus oppositifolius was evaluated for anti-inflammatory activity in rats and mice using acute and chronic anti-inflammatory models with acetylsalicylate acid (aspirin) as the reference drug. The antioxidant activity was done in vitro using ferric reducing antioxidant power (FRAP) and 1,1-diphenyl-2-hydrazyl (DPPH) spectrophotometric assays. The extract dose dependently and significantly reduced paw edema volume in rats induced by carrageenan (p<0.01), decreased croton oil-induced ear inflammation (p<0.05), inhibited cotton pellet-induced granuloma in mice and reduced the rat paw thickness in formalin-induced arthritis.
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