Abstract
Based on the traditional medical use in Thailand, the flowers of six medicinal plants were investigated for anti-inflammatory and anti-leukemic activities. In the screening, the n-hexane, dichloromethane, methanol and water extracts were tested for anti-inflammatory activity by the inducible nitric oxide synthase assay (iNOS) [1] and for anti-leukemic activity by a growth inhibition assay against human CCRF-CEM leukemia cell line [2]. The results from the iNOS assay showed that the tested extracts were only weak inhibitors with inhibition rates of 0–53% at 10µg/ml. The n-hexane extracts of Mammea siamensis (Miq.) T. Anderson, Mesua ferrea Linn. and the dichloromethane extracts of Mesua ferrea Linn. and Michelia alba DC. exhibited very strong cytotoxic effect against human CCRF-CEM leukemia cells at 10µg/ml with inhibition values of 85–99%. Bioassay-guided fractionation of the active extracts is in progress.
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