Abstract
Abstract Curcuma species has been reported to exert anti-inflammatory and anti-tumor effects. Curcuma wenyujin is mainly cultivated in wenzhou region of China and it was reported that the main constituents of Curcuma wenyujin is different from that of other Curcuma species. In this study, we investigated the effect of essential oil isolated from Curcuma wenyujin (CW) on inflammation and arthritis in rodents. CW dose-dependently suppressed lipopolysaccharide (LPS)-induced TNF-α production in mice. CW also inhibited zymosan-induced inflammation in concentration-dependent manner. Further studies demonstrated that CW attenuated the development of arthritis in adjuvant- and collagen-induced arthritis model and the anti-arthritic effect of the highest dose of CW was comparable to that of 0.1 mg/kg of dexamethasone. Collectively, the results presented in this report demonstrate that CW exerts anti-inflammatory and anti-arthritic effects. Our results suggest that CW might be a potential therapeutic agent for the treatment of inflammatory diseases, including rheumatoid arthritis.
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