Abstract
The purpose of this research is to evaluate the anti-inflammatory and analgesic activities of infusion and methanolic extract from avocado seeds. The anti-inflammatory activity was determined using carrageenan-induced paw edema in mice. The analgesic activity was assessed using acetic acid stimuli to induce peripheral pain in mice. Results of this research showed that both all level doses of infusion and methanolic extract of avocado seeds have a significant reduction on the mice paw edema. All level doses of methanolic extract of avocado seeds have a significant reduction on the number of abdominal writhes induced by acetic acid, but only the lowest dose of infusion showed a significant reduction. Our findings suggest that avocado seeds contains potential anti-inflammatory and analgesic compounds which support its traditional use. Further phytochemical studies are required to determine the active compounds are actually responsible for such properties.
Highlights
IntroductionInflammation is a protective response purposely to get rid of organism that causes injury (e.g. microbes and toxins) and the consequence of the injury (e.g. the damage of cell and tissue)
Inflammation is a protective response purposely to get rid of organism that causes injury and the consequence of the injury
In the process of inflammation, there is a process in which free radical compounds are generated (Ardhie, 2011)
Summary
Inflammation is a protective response purposely to get rid of organism that causes injury (e.g. microbes and toxins) and the consequence of the injury (e.g. the damage of cell and tissue). In the process of inflammation, there is a process in which free radical compounds are generated (Ardhie, 2011). Free radicals can cause tissue decay that triggers biosynthesis of arachidonic acid into prostaglandin as the mediator of inflammation (Sanchez et al, 2015). Excessive inflammatory responses or severe tissue decay should be handled immediately, inflammatory reaction should be treated to reduce signs and symptoms (Meliala and Pinzon, 2007). General symptoms of inflammation such as swelling, heat, pain, redness, and the loss of function can cause discomfort for the patient so that it needs to be handled (Supriyatna et al, 2015). Anti-inflammatory compounds and analgesic compounds are needed
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