Abstract
Since the discovery of adramatically potent antiphlogistic or antirheumatic effect of cortisone, a number of glucocorticoid derivatives were synthesized for pharmacological evaluation and some of them have been introduced to clinical use in rheumatic diseases and other various inflammatory disorders. The large doses or prolonged use of glucocorticoids, however, produced a variety of clinical side effects such as gastro-intestinal lesion and impaired protection against infection mainly due to adaptative adrenal atrophy and immunosuppression. Enthusiastic efforts to dissociate the therapeutic effects from adverse ones in chemical structure of glucocorticoids have all resulted in failure.
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