Anti-inflammatory activity of the essential oils of Cymbopogon validus (Stapf) Stapf ex Burtt Davy from Eastern Cape, South Africa.

Abstract

To evaluate the essential oil composition and the anti-inflammatory activity of Cymbopogon validus (C.validus) leaves and flowers. A total of 300g of fresh or dry (leaves and flowers) of C.validus were cut into small pieces and subjected to hydro-distillation method for approximately 5h using the Clevenger apparatus. The extracted essential oils were then used for testing the anti-inflammatory activity. The anti-inflammatory activity was evaluated by using egg albumin-induced paw edema. The extracted oils had the following yields 2.2% for fresh leaves, 2.0% for dry leaves and 2.4% v/w for dry flowers. GC-MS results revealed that the oils contained artemisia ketone (37.5%), linalool (3.2%-29.6%), northujane (4.4%-16.8%), verbenone (13.5%), naphthalene (1.7%-9.6%), δ-cadinene (0.5%-8.1%), hedycaryol (5.4%-7.6%) and α-eudesmol (6.5%-6.7%) as the major constituents. C.validus essential oils showed significant (P<0.05) anti-inflammatory effects from the first 30min after albumin injection compared to aspirin which had a later onset of effect. The findings of this study show that the essential oil extracted from C.validus fresh or dry leaves and flowers have anti-inflammatory properties; that might be associated with the major components and the minor components found in the essential oils.