Anti-inflammatory activity of the crude extract from the fruits of Pterodon emarginatus Vog

Abstract

The vegetal species Pterodon emarginatus Vog. (Leguminosae/Papilonaceae), popularly known in Brazil as ‘sucupira branca’, is widely used by domestic medicine as an anti-inflammatory. From these observations, the hexanic crude extract (HCE) of the fruits was obtained and submitted for assessment of its anti-inflammatory activity. For this purpose, the following tests were used: (1) Determination of ED 50 and LD 50; (2) Paw edema induced by carrageenin, dextran, histamine and nystatin; (3) Peritonitis caused by carrageenin and (4) Granuloma test. The ED 50 (oral) in the edema induced by carrageenin was 500 mg/kg, and LD 50 (oral) was 4.02 g/kg. In the edema caused by nystatin, there was a significant inhibition by 45% ( P< 0.05 student’s t-test) at the 6th hour following the treatment. In the granuloma test performed in animals treated with HCE, there was an inhibition of the granulomatous tissue formation by 22%. The migration of neutrophils towards the peritoneal cavity was inhibited in HCE treated animals by 43% ( P<0.05). However, in the edema caused by dextran and histamine, there was no significant response in HCE treated animals.