Abstract
The oleoresin from Brazilian Copaifera species yielded copalic acid and sesquiterpenes and showed marked anti-inflammatory activity using various experimental models in rats. The oleoresin significantly inhibited carrageenin-induced pedal edema following oral doses from 0.70 to 2.69 ml/kg, but was somewhat less effective than 50 mg/kg calcium phenylbutazone. Repeated administration of the oleoresin at a dose of 1.26 ml/kg for a 6-day period reduced granuloma formation with a response comparable to that of 20 mg/kg of calcium phenylbutazone. This same dose of oleoresin also reduced the vascular permeability to intracutaneous histamine. The LD 50 value of the oleoresin in rats was estimated to be 3.79 (3.21– 4.47) ml/kg.
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