Anti-inflammatory Activity of Ethanolic Leaf Extracts of Thaumatococus Danielli on Iodoacetamide Treated Rats

Abstract

Anti-inflammatory drugs such as Non-steroidal anti-inflammatory drugs (NSAIDs) are used to reduce swellings and pains caused by inflammation but, long term use of these anti-inflammatory drugs results in the damage of human biological system such as the liver, gastrointestinal tract, etc. Hence, there is need for safer, potent, anti-inflammatory drugs. Hence, the anti-inflammatory activity of ethanol leaf extract of Thaumatococcus danielli on iodoacetamide treated rats was investigated. Forty-two (42) rats were divided into seven groups of six rats each. Group 1 (positive control) received 1ml of 1% CMC; Group 2 (negative control) received 1ml of 1% CMC and 1ml of 0.1% iodoacetamide; Group 3 received 50mg/kg of extract (low dose) and 1ml of 0.1% iodoacetamide; Group 4 received 100mg/kg of extract (high dose) and 1ml of 0.1% iodoacetamide; Group 5 received 50mg/kg of extract (high dose) and 1ml of 1% CMC; Group 6 received 100mg/kg of extract (high dose) and 1ml of 1% CMC; Group 7 received 1ml 1% iodoacetamide and 2.14mg/kg diclofenac. Treatment with T. danielli extract showed no significant difference (p>0.05) in all groups in lymphocyte, RBC, granulocyte, platelet, hemoglobin concentration, hematocrit, mean corpuscular volume and mean corpuscular hemoglobin count but, a significant reduction in all groups was observed in ESR. Moreso, a significant decrease was observed in WBC in the high dose group, and a significant increase in group administered diclofenac. Ethanolic leaves extract of Thaumaococcus danielli possess an anti-inflammatory potential, possibly due to its embedded phytoconstituents. Keywords: Thaumatococcus danielli , Anti-inflammatory activity, Hematological studies, Erythrocyte sedimentation rate, Nitric oxide concentration DOI: 10.7176/JNSR/13-10-03 Publication date: May 31 st 2022