Abstract
Objective: To investigate the anti-inflammatory activity of the chloroform leaf extract of Palisota hirsuta (CLEPH). Methods: CLEPH was evaluated for anti-inflammatory activity using standard experimental models of inflammation namely: Croton oil-induced mouse ear edema, carrageenan-induced rat paw edema and cotton pellet granuloma test. The activities of the extract at different doses were compared to indomethacin, a standard anti-inflammatory drug. Results: In all the experiments, the chloroform extract of P. hirsuta showed in a dose-dependent manner, anti-inflammatory effects which were significant (p˂0.05) and comparable to those of indomethacin. Conclusion: The results showed that CLEPH possess significant anti-inflammatory activity. This supports its use as an anti-inflammatory recipe in folk medicine. Original Research Article Kelechi and Uzoma; JAMPS, 2(2): 57-63, 2015; Article no.JAMPS.2015.008 58
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