Abstract
Introdução: Os anti-inflamatórios não esteroides (AINEs) estão entre os medicamentos mais populares do mundo para o tratamento da dor e inflamação. Embora o uso a longo prazo de AINEs esteja associado a efeitos adversos renais, cardiovasculares, hepáticos e outros, também foi sugerido que ele pode causar comprometimento nas adaptações neuromuscular promovida pelo exercício. Objetivo: O objetivo desta revisão sistemática foi comparar os efeitos do uso de AINEs nas adaptações neuromusculares, como hipertrofia e força muscular em pessoas de meia-idade e idosos praticantes de treinamento resistido. Métodos: As bases de dados pesquisadas incluíram Bireme, Pubmed e Science Direct. As meta-análises foram conduzidas usando o método de estimativa de variância robusta de efeitos correlacionados com ajustes de pequenas amostras. Resultados: Seis estudos foram incluídos para análise meta-analítica, nenhuma diferença estatística foi encontrada para hipertrofia (ES: 0,000531 ± 0,0424, IC 95%: -0,123 - 0,124; P = 0,991) e força muscular (ES: 0,323 ± 0,213, 95% CI: -0,417 - 1,06; P = 0,258). Conclusão: Os achados desta revisão não sustentam a hipótese de que o uso de AINEs combinado com exercícios resistidos, influencie negativamente a hipertrofia e a força muscular.
Highlights
Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most popular drugs in the world for treating pain and inflammation
Eligibility criteria For inclusion of studies on the qualitative assessment were required: 1) randomized clinical trials, 2) assess subjects aged ≥ 50 years, 3) were performed resistance exercises, 4) there was a group making use of NSAIDs compared to a placebo group, 5) had a minimum duration of 4 weeks, 6) measured hypertrophy and muscle strength as a primary or secondary outcome
After a qualitative and meta-analytical assessment, the findings do not allow to state that the use of NSAID ibuprofen, combined with RT negatively results in the outcomes of hypertrophy and muscle strength
Summary
Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most popular drugs in the world for treating pain and inflammation. It is of utmost importance to understand the actions of NSAIDs during exercise since resistance training is effective and widely applicable to reverse or control changes in the neuromuscular system, such as loss of muscle mass and strength, associated with aging [7,8,9,10]. These changes result in annual reductions of 1% in muscle mass and between 2-4% in strength [11,12,13], leading to increased morbidities, disability, loss of autonomy, decreased quality of life, and mortality [14]
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