Abstract
Carps are able to synthesize xenogeneic anti-idio-typic antibodies against a mouse myeloma protein (S117) with specificity for N-acetyl-D-glucosamine. The properties of carp anti-idiotype (IgM) are compared to anti-idiotypic antisera from guinea pig (mainly IgG) elicited against the same idiotype. By radioprecipitin inhibition tests and passive hemagglutination inhibition tests, the specificity of carp and guinea pig anti-idiotypic antibodies is closely related. Furthermore, inhibition experiments with amino sugars suggest that at least some determinants localized in the antigen combining site of the S117 antibody are recognized by both carp and guinea pig anti-idiotypes. These results should contribute to the phylogenetic aspect of idiotype anti-idiotype interaction and possibly also of idiotype regulation.
Published Version
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