Abstract
Objective: Gongronema latifolium (Asclepiadiaceae) is used as bitter spice or flavouring agent in many traditional Nigerian dishes. It is well known for medicinal and nutritional purposes like anti-hyperglycemic, anti-oxidant, antitussive and widely distributed in the southeastern states of Nigeria. Objective of present study was to evaluate the anti-hyperglycemic and anti-oxidant effect of the methanol extract of Gongronema latifolium leaves. Methods: The methanol extract of G. latifolium at doses of 250 and 500 mg/kg were studied for anti-hyperglycemic effect in alloxan-induced hyperglycemic rats. The variation in blood glucose level in normal and experimental rats on 0, 7, 14 and 21 days of treatment has also been recorded. The effect of different treatment on body weight of rats was also determined. The antioxidant properties of the extracts as determined by the DPPH free radical scavenging assay. Results: Treatment with G. latifolium extract showed signs of recovery as comparable with the standard drug glibenclamide (0.25 mg/kg). The result showed that G. latifolium extract caused a concentration dependent percentage increase of antioxidant activity. Conclusion: Study concludes that methanol leaf extract of G. latifolium possesses significant anti-hyperglycemic and anti-oxidant activities. Peer Review History: Received 1 March 2017; Revised 7 April; Accepted 5 May, Available online 15 May 2017 Academic Editor: Dr. Emmanuel O. Olorunsola, Department of Pharmaceutics & Pharmaceutical Technology, University of Uyo, Nigeria, olorunsolaeo@yahoo.com Received file: Reviewer's Comments: Average Peer review marks at initial stage: 4.0/10 Average Peer review marks at publication stage: 7.5/10 Reviewer(s) detail: Dr. Heba M. Abd El-Azim, Damanhour University, Egypt, h_m_abdelazim@hotmail.com Dr. Leyla Açık, Gazi University, Ankara, Turkey, leylaacik@gmail.com Similar Articles: ANTI-INFLAMMATORY AND ANTI-OXIDANT ACTIVITIES OF METHANOL EXTRACT OF BAPHIA NITIDA
Highlights
Group II: Diabetic control Group III: Diabetic rats treated with G. latifolium extract (250 mg/kg) Group IV: Diabetic rats treated with G. latifolium extract (500 mg/kg)
The anti-hyperglycemic effect of methanol extract of cytotoxic action of alloxan is mediated by reactive
G. latifolium leaves was evaluated for 21 days
Summary
Plants are extremely an important source of medicinal agents. Since ancient times, plants have been used due to their impactful pharmacological properties. Diabetes mellitus is the commonest endocrine disorder that affects more than 171 million people worldwide It is a condition in which a person has a high blood sugar level. Antioxidants are substances known to protect the body from damage caused by reactive oxygen species induced oxidative stress[6]. Rats with fasting used as bitter spice or flavouring agent in many blood glucose >7.8 mmol/l or 140 mg/dl were traditional Nigerian dishes the plant leaves has been considered hyperglycemic and were selected for the found very efficacious as an antidiarrhoeal and study. Aerial parts are taken to treat cough, intestinal worms, dysentery, dyspepsia and malaria[9] It groups, each group contains six animals. A. Group I: Normal control decoction of leaves or leafy stems is commonly taken to treat diabetes and high blood pressure[10]. Group II: Diabetic control Group III: Diabetic rats treated with G. latifolium extract (250 mg/kg) Group IV: Diabetic rats treated with G. latifolium extract (500 mg/kg)
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