Abstract

Protective Effects of Vitamin-P and Vitamin-C on Hypercholesterolemia-induced Oxidative Hepatic Damage and Lipid Profile Changes in Female Rats: A Comparative StudyOsama A Alkhamees

Highlights

  • Cholesterol is a waxy, fat-like substance found in the blood and body cells of all humans and animals

  • The supplemented diets of 10% and 20% elastic pastry and roasted of unripe plantain, respectively, increases the concentration levels of high- density lipoprotein (HDL) of hypercholesterolemic rats with a significant difference when compared with the control group (p < 0.05)

  • The supplemented diets of 10% and 20% elastic pastry and roasted unripe plantain, respectively, caused a significant decrease in the concentration levels of plasma AST, ALT, and alkaline phosphatase (ALP) when compared with the control (P < 0.05)

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Summary

Introduction

Cholesterol is a waxy, fat-like substance found in the blood and body cells of all humans and animals It falls under one of the three major groups of lipids which are manufactured and utilized to build membranes in all kinds of animal cells. Hypercholesterolemia refers to a metabolic disorder which is caused by an elevated level in the concentrations of plasma lowdensity lipoprotein (LDL) cholesterol (Mu et al, 2017). It has been implicated as a primary risk factor for the pathogenesis of cardiovascular and many other related diseases due to the presence of high levels of cholesterol in the blood (Nelson and Cox, 2008). As part of combined activities to reduce hypercholesterolemia, several studies on the role/effects of traditional plants on hypocholesterolemia have been performed over the years

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