Abstract
Three artificial triterpenoids, (20 R)-20,25-epoxy-dammaran-2-en-6α,12β-diol ( 1), (20 R)-20,25-epoxy-3-methyl-28-nordammaran-2-en-6α,12β-diol ( 2) and isodehydroprotopanaxatriol ( 3), were isolated from an acidic hydrolysate of Panax ginseng C.A. Meyer, along with three known triterpenes, (20 R)-panaxadiol ( 4), (20 R)-panaxatriol ( 5) and oleanolic acid ( 6). Compounds 1– 3 and 6 showed inhibitory activity against HIV-1 protease with IC 50 of 10.5, 10.3, 12.3 and 6.3 μM, respectively. The results indicated that acid treatment of Ginseng extract could produce diverse structures with interesting bioactivity.
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