Abstract
Methods The HIV inhibitory activity of aqueous and methanolic extracts of S. swartzii was determined on laboratory adapted strains of HIV-1 clades C and A by indirectly measuring reduction in HIV-1 gag p24 antigen levels and inhibition of HIV-1 RT activity in supernatants of virus infected donor peripheral blood mononuclear cell (PBMC) cultures grown in varying concentrations of the extracts. Phytochemical analysis and cytotoxicity of the extracts was also undertaken.
Highlights
Available antiretrovirals are relatively expensive and have side effects
methanolic extracts of S. swartzii was determined on laboratory adapted strains of HIV-1 clades C
cultures grown in varying concentrations of the extracts
Summary
Dinesh Subramaniam[1], Thangam Menon1*, Hanna Luke Elizabeth[2], Soumya Swaminathan[2]. From 2nd International Science Symposium on HIV and Infectious Diseases (HIV SCIENCE 2014) Chennai, India. From 2nd International Science Symposium on HIV and Infectious Diseases (HIV SCIENCE 2014) Chennai, India. 30 January - 1 February 2014
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