Abstract
Abstract Silibinin (silybin A and silybin B), the primary active component of Silybum marianum has antiviral activity against herpes simplex virus, type 2 (HSV-2). The fifty percent cytotoxic dose (CD 50 ) of silibinin was 378 μg/ml. By plaque reduction assay silibinin had a weak antiviral effect against HSV-2 with a fifty percent inhibitory concentration (IC 50 ) of 100 μg/ml and therapeutic index of 3.8. As a virucide, silibinin was more potent with an IC 50 of 5 μg/ml and therapeutic index of 76. Further investigations of the mechanisms of action of silibinin against herpes simplex viruses and subsequent silibinin monotherapy or combination therapy with other flavonoids as a topical treatment for genital herpes are warranted.
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