Abstract
HCV is prevailed in the world as well as in China. Blood transfusion is one of the most common transmission pathways of this pathogen. Although data of HCV infection character were reported during the past years, anti-HCV reactive profile of China donors was not fully clear yet. Furthermore, infection progress was found related to the HCV genotype. Different genotype led to different efficacy when interferon was introduced into HCV therapy. Here we provided character data of HCV infection in China blood donors from the year of 2000 to 2009. The infection rate in local donors was lower than general population and descended from 0.80% to 0.40% or so in recent years. About 83% HCV strains were categorized into genotypes 1b and 2a. But 1b subtype cases climbed and 2a subtype cases decreased. The current study threw more light on HCV infection of blood donors in China, at least in the Northern region.
Highlights
Hepatitis C virus (HCV) infection rate is about 3% and more than 170 million people are currently infected by HCV in the world [1]
Infection rate in the last 10 years decreased To determinate the HCV infection rate in local blood donors, ELISA was performed according to the standard donor peripheral blood test procedure
In the year of 2010, HCV infection rate is 0.54% hitherto (117/21578, up to 31st May, 2010).Those data implied that anti-HCV reactive donors decreased in the latest 5 years in local region
Summary
Hepatitis C virus (HCV) infection rate is about 3% and more than 170 million people are currently infected by HCV in the world [1]. The situation is more serious in China because more than 50 million HCV cases located in this country [3]. This infection, mainly transmitted by blood transfusion in China, could progress to cirrhosis liver and hepatocarcinoma [4]. HCV is an enveloped virus with a single strand positive and non- fragment RNA. The genome of HCV is about 9 400 nucleotides, which encodes approximately 3 000 amino acids [5]. The high heterogenic nucleotides of HCV were confirmed and at least six different genotypes have generally been divided [6,7]. HCV quasispecies were clarified according to more detailed HCV genome variation [8,9,10]
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