Abstract
The study was done to investigate the in vitro anti-diabetic activity of Ethanol-water extract of Abutilon indicum plant leaves. The phytochemicals present in the extract was analyzed by using standard methods. In vitro antioxidant study was done using DPPH radical scavenging activity. The In vitro anti-diabetic studies were done by alpha amylase enzyme, alpha glucosidases enzyme inhibition studies and Glucose uptake in Yeast cells studies. The phytochemical analysis showed that the extract rich with proteins, polyphenols, flavonoids, alkaloids, tannins, polysaccharides. The in vitro antiglycation potential of extract was confirmed through alpha amylase enzyme, alpha glucosidases enzyme inhibition studies and Glucose uptake in Yeast cells studies. The results of the present study showed the significant antioxidant and antidiabetic activity. The potential pharmacological activity of Abutilon indicum might be the presence of phytochemicals.
Highlights
Many chronic diseases like Cancer, Alzheimer disease, Parkinson disease, Diabetes, Cardio vascular diseases, Inflammation, Viral infections, Autoimmune pathologies, etc are due to vital role of reactive oxygen species (ROS) [1,2,3]
The In vitro anti-diabetic studies were done by alpha amylase enzyme, alpha glucosidases enzyme inhibition studies and Glucose uptake in Yeast cells studies
The in vitro antiglycation potential of extract was confirmed through alpha amylase enzyme, alpha glucosidases enzyme inhibition studies and Glucose uptake in Yeast cells studies
Summary
Many chronic diseases like Cancer, Alzheimer disease, Parkinson disease, Diabetes, Cardio vascular diseases, Inflammation, Viral infections, Autoimmune pathologies, etc are due to vital role of reactive oxygen species (ROS) [1,2,3]. A non-enzymatic reaction like Glycation takes place in amino groups of proteins and reducing sugars [7,8]. This process is associated with the pathogenesis of age and diabetes related complications. From Vedic period, India is one of the most medico- culturally diverse countries in the world where the medicinal plant sector is a part of time- honored tradition had value even today. The various parts of the plant Abutilon such as roots, leaves, bark, seeds and even flowers are documented to possess various medicinal properties in ethnobotanical surveys conducted by ethnobotanists and in traditional systems of medicine such as Ayurveda [12]. Since large variety of compounds have been isolated from genus Abutilon and majorities of them are flavonoids, steroids, terpenoids and phenolics [14]
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