Abstract
Background: Piper sarmentosum or “Kaduk” had been utilized for treating human diseases in traditional medicine. Aim and Objectives: Previous studies provided evidence for its therapeutic properties such as antimicrobials, anticholesterolemic, and antioxidant. An antifungal agent is highly important to cure diseases caused by pathogenic fungi. Materials and Method: Thus, the aim of this study is to discover the antifungals activity of P.sarmentosum leaves& aqueous and ethanolic extracts against four pathogenic fungi, namely Candida albicans, Aspergillus niger, Fusarium verticillioides, and Microsporum gypseum. Result: The yield percentage of the aqueous extract was 17.72%, followed by ethanolic extract with 11.95% of yield. Phytochemical analysis by gas chromatography–mass spectrometer showed the presence of acetic acid, hydrocinnamic acid, oxazole, guanidine, pyranone, benzofuran, β-asarone, and 1-pentadecene in aqueous extracts, while it showed the presence of β-asarone, β-asarone, myristicin, apiol, isocaryophyllene, 1,1-dichlorocyclopentane, and 14-chloro-1-tetradecanol in ethanolic extract. Conclusion: The antifungal susceptibility by disc-diffusion test found that the inhibition growth on F.verticillioides by the aqueous extract occurred at a concentration of 100 mg/mL with an average diameter of 7.3 mm ± 0.06. C. albicans, A. niger, and M. gypseum were shown to be insusceptible to both the extracts.
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