Abstract
<p class="Abstract">The aim of this review is to report the medicinal plants which have anti- fibrotic effect characterized in different studies. They are summarized which include name of the plants, part used, liver fibrosis model, fraction of plant used and observations. The medicinal plants play an important role in treatment and prevention of liver fibrosis through different physiological mechanism. The effects of medicinal plant may delay the development of liver fibrosis and have potential to reverse or degrade the accumulation of extra cellular matrix. Four different databases are used and 18 plants are included which have the potential for reversal of liver fibrosis. There are also few more plants but they are not characterized well in literature.</p>
Highlights
Worldwide 80% of people rely on the use of traditional medicine and these have a characteristic role in human health care system (WHO, 1993)
After continuous injury oxidative stress is produced by several sources can influence liver fibrosis
The therapeutic potential for the liver fibrosis of the plant was assessed through rat and mouse model of the liver injury
Summary
Worldwide 80% of people rely on the use of traditional medicine and these have a characteristic role in human health care system (WHO, 1993). The root extract has protective effect in the liver injury of rat model induced by continuous administration of CCl4. Comparison of malondialdehyde (MDA) and hydroxyproline in the liver and enzyme activities in the serum of CCl4-treated rat showed a significant increase when compared to rat treated with plant extract. The root is pharmacologically important to prevent acute liver damage and reduces the liver fibrosis induced by CCl4 in animal model (Lee et al, 2003; Nan et al, 2001; Qi, 1991).
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