Anti fertility activity of hydro alcoholic extract of Trillium govanianum in Ethinyl Estradiol induced anti fertility model in rats

Abstract

Lack of fertility is in fertility were as anti-fertility is to reduce fertility. Fertility is burning issue of global as well as national public issue which are concerning the fast growth of the country. Increase rate of population has got and adverse effect on the economy of the countries. So there is an urgent and important need for the anti fertility services in the country. In present study anti implantation and anti estrogenic activity of hydro alcoholic extract of Trillium govanianum was evaluated in Ethinyl estradiol induced anti fertility model. Obtained result suggests that Trillium govanianum at the doses of 250 and 500 mg/kg body weight produced a dose dependent adverse effect on fertility index and number of implantation in the uterine horns of the female rats by virtue of an increase in the percentage of the post implantation embryonic loss. All the experimental extract when evaluated for their abortifacient activity, were found to exhibit pregnancy interceptive activity. Administration of 100 mg/kg body weight of the alcoholic extract resulted in 100% abortion, while doses of 250 and 500 mg/ kg body weight of the alcoholic extract resulted in 28.50% and 44.45% abortion. This was evident from decrease in the percentage of live fetuses. The percent resorption index increased from zero in the control animals to 100 % in 100 mg/kg body weight alcoholic extract treated animals.